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If insulin therapy is interrupted for more than 24-48 hours, then skin tests and desensitization should be repeated. With a high titer of IgG antibodies to insulin, insulin resistance usually develops. A rare form of insulin resistance associated with the appearance of antibodies to tissue hormone receptors is combined with acanthosis nigricans and lipodystrophy. Almost 30% of patients with insulin resistant diabetes mellitus also have an allergy to insulin. In about 50% of cases, the transfer of patients to less immunogenic hormone preparations, selected using skin tests, helps.
phone: (803) 926-5243
Anticonvulsants can cause severe anaphylactic reactions. Hypersensitivity to these agents seems to be associated with hereditary deficiency of epoxide hydrolase, an enzyme that degrades aryl oxide intermediates in the metabolism of cialis in the liver. Fever, maculopapular rash, generalized lymphadenopathy, and visceral involvement are characteristic. A similar syndrome occurs with the introduction of minocycline, sulfonamides and dapsone.
In such cases, either other diagnostic methods or low-osmolar contrast agents should be used while taking prednisone, diphenhydramine, and salbutamol. Sometimes H2 blockers (cimetidine or ranitidine) are also added.
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